The 54th ACM Symposium on Theory of Computing (STOC 2022) is sponsored by the ACM Special Interest Group on Algorithms and Computation Theory and will be held in Rome, Italy Monday June 20 – Friday, June 24, 2022. It will be part of a 5-day TheoryFest that will feature six workshops with introductory tutorials, technical talks and poster sessions, social events, and a special joint session with ``Accademia Nazionale dei Lincei'', the oldest and most prestigious Italian academic institution, followed by a reception and a concert at the Academy historic site. Organizers: General Chair: Stefano Leonardi (Sapienza University of Rome) Program Committee Chair: Anupam Gupta (Carnegie Mellon University) Theory Fest Organizing Committee: Leonard Schulman (Chair), Nina Balcan, Shuchi Chawla, Fabrizio Grandoni, Yael Kalai, James Lee, Yuval Rabani, Rocco Servedio, Mary Wooters. Workshops Chair: Shuchi Chawla. Keynote Talks Chair: James Lee. Social Activities Co-Chairs: Clement Cannone, Mary Wooters. TCS Women Meeting Organizers: Elena Grigorescu (Purdue University), Barna Saha (UC Berkeley), Virginia Vassilevska Williams (Massachusetts Institute of Technology), and Mary Wootters (Stanford University) SafeToC advocates: Éva Tardos, Tom Gur, and Yuval Rabani.