The 41st International Symposium on Reliable Distributed Systems (SRDS 2022) is a forum for researchers and practitioners interested in distributed systems design, development and evaluation, with an emphasis on reliability, availability, safety, dependability, security, verification, and real-time aspects. The major areas of interest include the following topics: Dependability, security and privacy of distributed systems including, but not limited to, cloud, high-performance, fog, and edge computing; distributed data storage and processing; distributed machine learning and AI; safety-critical distributed systems; Internet of Things, vehicular, robotic, cyber-physical and mobile systems. Techniques and algorithms advancing the state-of-the-art in fault tolerance, fault recovery, robustness, self-stabilization, self-healing, scalability, and real-time for distributed systems. These include, but are not limited to, coordination, replication, failure prediction and detection, micro-services, transactions, and blockchains. Methods and tools for the design, implementation, verification, validation, and operation of dependable and secure distributed applications, middleware, operating systems, virtual machines and hardware. Analytical, simulative and experimental assessment of dependable and secure distributed systems, in particular, when in real-world settings or with real-world data and in large scale and complex environments.