The IEEE Real-Time Systems Symposium (RTSS) is the premier conference in the field of real-time systems and is a venue for researchers and practitioners to showcase innovations covering all aspects of real-time systems, including theory, design, analysis, implementation, evaluation, and experience. RTSS ’22, celebrating the 43rd anniversary of the event, continues the trend of making RTSS an expansive and inclusive event, striving to embrace new and emerging areas of real-time systems research. General Chair Liliana Cucu-Grosjean INRIA, France Program Chair Arvind Easwaran Nanyang Technological University, Singapore Local Organization Chair Albert Cheng University of Houston, USA Publications Chair Jinkyu Lee Sungkyunkwan University, Republic of Korea Topics include (but are not limited to): autonomous systems, such as autonomous vehicles and robots, real-time machine learning, real-time cloud/edge computing, safety, reliability and security of learning-based and autonomous systems, industrial automation, smart manufacturing and industry 4.0, 5G-enabled real-time applications, cyber-physical systems and internet-of-things.