The 25th IEEE International Conference on Intelligent Transportation Systems (ITSC 2022) is the annual flagship conference sponsored by the IEEE Intelligent Transportation Systems Society. IEEE ITSC 2022 welcomes papers and presentations in the field of Intelligent Transportation Systems, conveying new developments in theory, analytical and numerical simulation and modeling, experimentation, advanced deployment and case studies. ITSC 2022 particularly invites and encourages prospective authors to share their work, findings, perspectives and developments as related to implementation and deployment of advanced ITS applications.