ISWC 2022 is the premier international forum for the Semantic Web and Knowledge Graph Community. ISWC2022 will bring together researchers, practitioners and industry specialists to discuss, advance, and shape the future of semantic technologies. Every year ISWC offers five exciting and fruitful days that you definitely don’t want to miss! We encourage papers that directly contribute to the advancement of the Semantic Web area. The relationship to the core area of the conference needs to be clearly described in the submitted work. Topics in this area include, but are not limited to: Management, search and querying of graphs (e.g. RDF and knowledge graphs) Knowledge representation, ontologies, rules, and reasoning Semantic Web meets … machine learning; information extraction; natural language processing; data integration; user interfaces, usability and accessibility; data quality; trust, provenance, privacy, security and social issues; software; Web services, Social Web, Internet of Things; dynamic and streaming data; specialized domains (geographical, biomedical, multimedia, etc.); and so forth.