The 2022 Symposium explores emerging trends and novel ideas and concepts covering a broad range of topics in the area of VLSI: from VLSI circuits, systems and design methods, to system level design issues, to bringing VLSI design to new areas and technologies such as nano- and molecular devices, security, artificial intelligence, and Internet-of-Things, etc. Future design methodologies and new EDA tools are also a key topic at the Symposium. The ISVLSI proceedings will be indexed in the IEEE Xplore Digital Library. Selected high quality papers will be further invited for submission to a journal special issue.